Fractional CO2 Lasers are the most traditional and basic lasers in Dermatology. They have replaced diathermy and cryotherapy in benign skin lesions. They are mostly used in treating warts, papillomas, seborrheic keratosis, genital warts, xanthelasma, neurofibromas, pyogenic granuloma, pigmentation, intradermal nevi, small hemangiomas, and generally all benign skin lesions.